Niraparib

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Shandong Sihuan Pharmaceutical Co., Ltd

Business Type:Manufacturer

Country/Region:China

Ddu Verified

HOT Rank

6/10

Product Information

  • CAS:1038915-60-4
  • Chemical Formula:C₁₉H₂₀N₄O
  • Molecular Weight:320.39
  • Pharmacopeia:CP
  • Shelf Life:2 years
  • Storage:Sealed

Description

Niraparib is a poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, which is highly selective for PARP-1 and PARP-2. PARP-1 and PARP-2 are involved in detecting DNA damage and promote repair (Mirza 2016). Inhibiting PARP enzymatic activity results in DNA damage, apoptosis and cell death. Niraparib induces cytotoxicity in tumor cell lines with and without BRCA1/2 deficiencies.

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