Niraparib- Shandong Sihuan Pharmaceutical Co., Ltd

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Niraparib

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Min.Order:1 Kg(s)
Payment Terms:L/C , T/T

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Shandong Sihuan Pharmaceutical Co., Ltd

Business Type:Manufacturer

Country/Region:China

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HOT Rank

8/10

Product Information

CAS:1038915-60-4
Chemical Formula:C₁₉H₂₀N₄O
Molecular Weight:320.39
Pharmacopeia:CP
Shelf Life:2 years
Storage:Sealed

Description

Niraparib is a poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, which is highly selective for PARP-1 and PARP-2. PARP-1 and PARP-2 are involved in detecting DNA damage and promote repair (Mirza 2016). Inhibiting PARP enzymatic activity results in DNA damage, apoptosis and cell death. Niraparib induces cytotoxicity in tumor cell lines with and without BRCA1/2 deficiencies.